What is VOTRIENT (Pazopanib)?
VOTRIENT is a prescription medicine used to treat people with:
- Advanced renal cell cancer (RCC)
- Advanced soft tissue sarcoma (STS) who have received chemotherapy in the past
- It is not known if VOTRIENT is effective in treating certain soft tissue sarcomas or certain gastrointestinal tumors.
It is not known if VOTRIENT is safe and effective in children under 18 years of age.
What is the most important information I should know about VOTRIENT?
- VOTRIENT can cause serious liver problems including death. Your healthcare provider will do blood tests to check your liver before you start and while you take VOTRIENT.
- Tell your healthcare provider right away if you get any of these signs of liver problems during treatment with VOTRIENT:
- Yellowing of your skin or the whites of your eyes (jaundice)
- Dark urine
- Tiredness
- Nausea or vomiting
- Loss of appetite
- Pain on the right side of your stomach area (abdomen)
- Bruise easily
VOTRIENT can cause serious side effects. These serious side effects include:
- VOTRIENT can cause serious liver problems including death.
- Irregular or fast heartbeat or fainting
- Heart failure. This is a condition where your heart does not pump as well as it should and may cause you to have shortness of breath.
- Heart attack or stroke. Heart attack and stroke can happen with VOTRIENT and may cause death.
- Blood clots. Blood clots may form in a vein, especially in your legs (deep vein thrombosis or DVT). Pieces of a blood clot may travel to your lungs (pulmonary embolism). This may be life threatening and cause death.
- Bleeding problems. These bleeding problems may be severe and cause death
- Tear in your stomach or intestinal wall (perforation) or an abnormal connection between two parts of your gastrointestinal tract (fistula).
- Reversible Posterior Leukoencephalopathy (RPLS).
- High blood pressure.
- Collapsed lung (pneumothorax).
- Thyroid problems
- Protein in your urine
- Symptoms may include:
- Chest pain or pressure
- Pain in your arms, back, neck & Jaws
- Shortness of breath
- Numbness or weakness on one side of your body
- Trouble talking
- Swelling in your stomach-area
- Headache
- Dizziness
- Unusual bleeding
- Bruising
- Wounds that do not heal
- Vomiting blood
- Black sticky stools
- Call your healthcare provider right away, if you have any of the symptoms listed above
How should I take VOTRIENT?
- Take VOTRIENT exactly as your healthcare provider tells you. Your healthcare provider will tell you how much VOTRIENT to take.
- Your healthcare provider may change your dose.
- Take VOTRIENT on an empty stomach, at least 1 hour before or 2 hours after food.
- Do not crush VOTRIENT tablets.
- Do not eat grapefruit or drink grapefruit juice during treatment with VOTRIENT. Grapefruit products may increase the amount of VOTRIENT in your body.
- If you miss a dose, take it as soon as you remember. Do not take it if it is close (within 12 hours) to your next dose. Just take the next dose at your regular time. Do not take more than 1 dose of VOTRIENT at a time.
- Your healthcare provider will test your urine, blood, and heart before you start and while you take VOTRIENT
- Tell your healthcare provider if you plan to have surgery while taking VOTRIENT. You will need to stop taking VOTRIENT at least 7 days before surgery because VOTRIENT may affect healing after surgery.
Important Safety Information
Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. VOTRIENT may affect the way other medicines work and other medicines may affect how VOTRIENT works.
What should I tell my healthcare provider before taking _______?
- Have or had liver problems. You may need a lower dose of VOTRIENT or your healthcare provider may prescribe a different medicine to treat your advanced renal cell cancer or advanced soft tissue sarcoma.
- Have high blood pressure
- Have a history of a stroke
- Have heart problems or an irregular heartbeat including QT prolongation
- Have headaches, seizures, or vision problems
- Have coughed up blood in the last 6 months
- Had bleeding of your stomach or intestines in the last 6 months
- Have a history of a tear (perforation) in your stomach or intestine, or an abnormal connection between two parts of your gastrointestinal tract (fistula)
- Have had blood clots in a vein or in the lung
- Have thyroid problems
- Had recent surgery (within the last 7 days) or are going to have surgery
- Have any other medical conditions
- Are pregnant or plan to become pregnant. VOTRIENT can harm your unborn baby. You should not become pregnant while you are taking VOTRIENT
- Are breastfeeding or plan to breastfeed. It is not known if VOTRIENT passes into your breast milk. You and your healthcare provider should decide if you will take VOTRIENT or breastfeed. You should not do both
- Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements
General information about VOTRIENT
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use VOTRIENT for a condition for which it was not prescribed. Do not give VOTRIENT to other people even if they have the same symptoms that you have. It may harm them
What are the ingredients in VOTRIENT?
Active ingredient: Pazopanib
Other ingredient: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate