NINLARO® (nin-LAR-oh) (Ixazomib)
Learn about this cancer-treatment related side effect, practical management information and when to seek medical attention.
What is NINLARO (Ixazomib)?
NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.
It is not known if NINLARO is safe and effective in children.
What is the most important information I should know about NINLARO ?
NINLARO can cause serious side effects. These serious side effects include:
- Low platelet counts (thrombocytopenia). Low platelet counts are common with NINLARO, and can sometimes be serious. You may need platelet transfusions if your counts are too low. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising.
- Stomach and intestinal (gastrointestinal) problems. Diarrhea, constipation, nausea, and vomiting are common with NINLARO, and can sometimes be severe. Call your healthcare provider if you get any of these symptoms and they do not go away during treatment with NINLARO. Your healthcare provider may prescribe medicine to help treat your symptoms.
- Nerve problems. Nerve problems are common with NINLARO and may also be severe. Tell your healthcare provider if you get any new or worsening symptoms, including:
- Tingling
- Numbness
- Pain
- A burning feeling in your feet or hands
- Weakness in your arms or legs
- Swelling. Swelling is common with NINLARO and can sometimes be severe. Tell your healthcare provider if you develop swelling in your arms, hands, legs, ankles, or feet, or if you gain weight from swelling.
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- Skin reactions. Tell your healthcare provider if you get a new or worsening rash.
- Liver problems. Tell your healthcare provider if you get these signs of a liver problem: Yellowing of your skin or the whites of your eyes, Pain in your right upper stomach-area.
- Back pain is also common with NINLARO.
How should I take NINLARO?
- Take NINLARO exactly as your healthcare provider tells you to take it. Do not change your dose or stop taking NINLARO without talking to your healthcare provider first
- NINLARO is taken in “cycles.” Each cycle lasts 4 weeks (28 days).
- The usual dose of NINLARO is 1 capsule taken 1 time each week, on the same day of the week for the first 3 weeks of each cycle.
- Take each dose of NINLARO at about the same time of day.
- Take REVLIMID (lenalidomide) and dexamethasone exactly as your healthcare provider tells you to.
- Your healthcare provider will do blood tests during treatment with NINLARO to check for side effects.
- Your healthcare provider may change your dose or stop NINLARO, REVLIMID (lenalidomide), or dexamethasone if you have side effects.
- Take NINLARO at least 1 hour before or at least 2 hours after food.
- On the days that you take both NINLARO and dexamethasone, do not take NINLARO and dexamethasone at the same time. Take dexamethasone with food.
- Swallow NINLARO capsules whole with water. Do not crush, chew or open the capsule
- Avoid direct contact with the capsule contents. If you accidentally get powder from the NINLARO capsule on your skin, wash the area well with soap and water. If you accidentally get powder from the NINLARO capsule in your eyes, flush your eyes well with water.
- If you miss a dose of NINLARO, or if you are late taking a dose, take the dose as long as the next scheduled dose is more than 3 days (72 hours) away. Do not take a missed dose of NINLARO if it is within 3 days (72 hours) of your next scheduled dose.
- If you vomit after taking a dose of NINLARO, do not repeat the dose. Take your next dose of NINLARO on the next scheduled day and time.
- If you take more NINLARO than your healthcare provider tells you to take, call your healthcare provider right away or go to the nearest hospital emergency room.
Important Safety Information
- Take NINLARO at least 1 hour before or at least 2 hours after food.
- On the days that you take both NINLARO and dexamethasone, do not take NINLARO and dexamethasone at the same time. Take dexamethasone with food.
- If you accidentally get powder from the NINLARO capsule on your skin, wash the area well with soap and water. If you accidentally get powder from the NINLARO capsule in your eyes, flush your eyes well with water.
- Avoid becoming pregnant during treatment with NINLARO.
- Males with a female partner who is able to become pregnant must use effective birth control during treatment and for 90 days after your final dose of NINLARO
- If you miss a dose of NINLARO, or if you are late taking a dose, take the dose as long as the next scheduled dose is more than 3 days (72 hours) away. Do not take a missed dose of NINLARO if it is within 3 days (72 hours) of your next scheduled dose.
- If you take more NINLARO than your healthcare provider tells you to take, call your healthcare provider right away or go to the nearest hospital emergency room.
Ask your healthcare provider if you do not know.
What should I tell my healthcare provider before taking NINLARO?
Tell your healthcare provider about all of your medical conditions, including if you:
- Have liver problems
- Have kidney problems or are on dialysis
- Are pregnant or plan to become pregnant. NINLARO can harm your unborn baby.
- Are breastfeeding or plan to breastfeed. It is not known if NINLARO passes into breast milk. Do not breastfeed during treatment with NINLARO.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Talk to your healthcare provider before starting any new medicines during treatment with NINLARO.
General information about NINLARO
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use NINLARO for a condition for which it was not prescribed. Do not give NINLARO to other people, even if they have the same symptoms that you have. It may harm them.
What are the ingredients in _________?
Active ingredient: Ixazomib
Inactive ingredient: Microcrystalline cellulose, magnesium stearate, and talc Capsule shells: gelatin and titanium dioxide. The 4 mg capsule shell contains red and yellow iron oxide. The 3 mg capsule shell contains black iron oxide. The 2.3 mg capsule shell contains red iron oxide. The printing ink contains shellac, propylene glycol, potassium hydroxide, and black iron oxide.